• About This site
• Drs.Imai and Guarente
• Dr.Sinclair
• Dr.Haigis
• Dr.Vlasuk

As a world leader in aging research, Dr. Guarente has been revealing the relationship between aging and sirtuins and producing more than 190 scientific papers. He has also mentored many great scientists who are now leading authorities in many different institutions. Dr. Imai has also been fascinated with aging science for more than 20 years and recently trying to understand the systemic regulation of aging and longevity through his concept of the NAD World. Drs. Guarente and Imai have made a phenomenal discovery of sirtuins’ NAD-dependent deacetylase activity in 2000, which has opened a new arena of aging research.

In this interview, Drs. Guarente and Imai talk about the history of their aging science and sirtuin research, important connections between sirtuins and brain function, and their visions of next ten years of sirtuin biology.

Streaming Video Clips

• The Past and The Next Ten Years of Sirtuin Research
• Shin-ichiro Imai, M.D., Ph.D., Leonard P. Guarente, Ph.D.
• 6:57 [November 22nd, 2010]

• The development of sirtuin research in the past decade
• Shin-ichiro Imai, M.D., Ph.D., Leonard P. Guarente, Ph.D.
• 10:24 [November 22nd, 2010]
• Challenges in aging science: From cellular aging to organismal aging［3:17］／The serendipitous discovery of sirtuin function［6:27］

• The novel functions of sirtuins in the brain and the next milestone in sirtuin biology
• Shin-ichiro Imai, M.D., Ph.D., Leonard P. Guarente, Ph.D.
• 9:26 [November 30th, 2010]
• The novel functions of sirtuins in the brain［4:55］／The visions on the next ten years of sirtuin research［3:51］

• Opening new paradigms of science
• Shin-ichiro Imai, M.D., Ph.D., Leonard P. Guarente, Ph.D.
• 9:07 [December 7th, 2010]
• Training young talented researchers as a mentor［2:42］／Enjoying science to overcome difficulties［3:04］／Messages for young scientists［2:42］